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S-ADENOSYLMETHIONINE (SAMe: ​​pronounce “samy“)

SAMe is a physiological substance synthesized by the body from an essential amino acid, methionine, and adenosine triphosphate (ATP). Biochemically, SAMe is the most potent methyl donor.

METHYLATION

Most people have never heard of methylation, but without it we would all be dead.

Like oxidation, methylation is a biochemical process which corresponds to the transfer of a methyl group, composed of one carbon atom and three hydrogen atoms (ch3), from one molecule to another molecule. Stated this way, it doesn't sound exciting, yet the end result is paramount.

This is because carbon is present in every organic substance on earth, and when carbon atoms move, a lot of things change. To understand methylation, you have to think of the human body as a car. Methylation is the spark plug. Without it everything stops, because methylation is involved in more than a hundred biochemical reactions in our body.

In summary, it can be said that methylation is involved in DNA repair and plays a role in the body's ability to repair damaged cells before they become cancerous. Methylation of proteins is essential for communication between cells by activating membrane receptors, while methylation of phospholipids helps maintain the flexibility and permeability of cell membranes, which are essential for exchanges between cells. Methylation is needed to make our most important antioxidant: Glutathione.

It also makes adrenaline from norepinephrine, and melatonin from serotonin and largely regulates brain activity. Besides the brain, the liver also uses methylation to perform its role of detoxifying the body. The effects of under-methylation can be seen in premature aging, cancer, cardiovascular disease, liver disease and depression. SAMe is the only product that can enhance methylation.

As methylation activity declines with age, many specialists now believe that Indications: Methylation this slowing down contributes to the aging process and the development of several diseases.

SAMe and depression

SAMe has been the subject of numerous clinical studies which have demonstrated its effectiveness in treating depression, even severe, in patients who had not obtained results with conventional anti-depressants. These studies have also made it possible to explain the mode of action of SAMe which is to increase the levels of certain brain hormones called neurotransmitters: noradrenaline (natural stimulant), dopamine (responsible for the feeling of well-being) and serotonin (natural calming).

SAMe and melatonin

SAMe is essential for the production of melatonin. Indeed, the synthesis of melatonin during the night depends on the synthesis of SAMe during the day. SAMe is essential for converting serotonin into melatonin. There is a circadian rhythm between SAMe and melatonin: when melatonin levels rise overnight, SAMe levels stay low, and when melatonin levels drop during the day, SAMe levels rise. If there is a deficiency in SAMe synthesis during the day, there will be a deficiency in melatonin synthesis at night. However, we know the essential role of melatonin which regulates and controls our biological clock: it improves sleep, stimulates the immune system and protects the central nervous system.

SAMe and the liver

SAMe increases the production of Glutathione which plays a major role in the hepatic detoxification process. It can be used to treat serious liver conditions like hepatitis and cirrhosis. Its hepatoprotective action makes it a nutritional supplement of choice for alcohol consumers.

SAMe and fibromyalgia

In 1991, in a clinical trial involving 44 patients with fibromyalgia, researchers observed significant improvements in pain, fatigue, morning stiffness and mood in those treated. by SAMe.

SAMe and osteoarthritis

SAMe (400 to 1200 mg per day) relieves pain as effectively as drugs.{show-else}Please login respectively register here as a member of healing professions to gain full access to restricted, product-related contents.